Succinylcholine-induced Hyperkalemia in Acquired Pathologic States Etiologic Factors and Molecular Mechanisms J. A. Jeevendra Martyn, M.D., F.R.C.A., F.C.C.M.,* Martina Richtsfeld, M.D.,†Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated. In the normal innervated mature muscle, the acetylcholine receptors (AChRs) are located only in the junctional area.
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