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Marginal Furrow
Marginal corneal thinning without obvious inflammatory cell infiltration into the cornea and without an overlying epithelial defect may occur in patients with rheumatoid arthritis. The cause of this marginal furrows, which often are in the inferior aspect of the cornea, is unknown. The corneal epithelium is intact over the progressively thinning cornea, and changing degrees of corneal astigmatism may result. The lesions rarel progres to the point of threatened perforation, do not vascularize, and have no known effective treatment. Systemic collagenase inhibitors, such as tetracycline and doxycyline, may slow progression of these lesions.