Original text - Engels - INTRODUCTION Treatment of recurrent idiopathic...

INTRODUCTION
Treatment of recurrent idiopathic nephrotic
syndrome in children is often complicated by the
toxicity of the therapeutic regimen with
corticosteroids, alkylating substances or
cyclosporine. An alternative is the treatment with
levamisole, a potent anthelmintic compound with
immuno-modulating properties (1-3). In children,
levamisole is given orally as 2 - 5 mg/kg daily or
every other day depending on the patient response
(4-6). Levamisole is commercially available only in