Original text - Engels - Succinylcholine-induced Hyperkalemia in Acquired...

Succinylcholine-induced Hyperkalemia in Acquired
Pathologic States
Etiologic Factors and Molecular Mechanisms
J. A. Jeevendra Martyn, M.D., F.R.C.A., F.C.C.M.,* Martina Richtsfeld, M.D.,†
Lethal hyperkalemic response to succinylcholine continues
to be reported, but the molecular mechanisms for the hyperkalemia
have not been completely elucidated. In the normal innervated
mature muscle, the acetylcholine receptors (AChRs)
are located only in the junctional area.