Original text - Engels - The established tumours in the castrated mice...

The established tumours in the castrated mice were the either treated with oestrogen withdrawal alone (supposed to mimic anastrozole induced oestrogen withdrawal) or oestrogen witdrawal plus treatment with fulvestrant. In contrast, in mice treated with oestrogen withdrawal plus fulvestrant it took twice as long time for tumours to progress and in some tumours development of resistance was not evident.